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Lancet 1991;338:131-7 American Academy of Pediatrics (AAP) Committee on Drugs

Key Clinical Studies Study 1: Wrinkle Reduction in Women A clinical study involving female participants demonstrated that after just 2 months of treatment with Matrixyl 3000: Deep wrinkles were reduced by 45% Skin tonicity increased by nearly 20% Overall skin texture showed significant improvement Study 2: Men's Anti-Aging Trial In a separate 2-month study conducted on men: Wrinkle volume decreased by 17.1% The spread angle increased by 5.4% The surface area occupied by deep wrinkles was reduced by nearly 30% Study 3: Collagen Production A study published in the International Journal of Cosmetic Science (2013) found that: Matrixyl 3000 increased skin elasticity by 13% after 12 weeks Skin moisturization improved by 19% Participants showed measurable increases in dermal thickness Study 4: Gene Expression Research has shown that Matrixyl 3000 influences gene expression related to: Upregulation of genes responsible for collagen types I, III, and IV synthesis Increased production of fibronectin and laminin Enhanced expression of tissue inhibitors of metalloproteinases (TIMPs), which protect existing collagen from degradation What Results Can You Expect

However, it remained untested whether 4-OXO-DHA could be detected in vivo following DHA administration